Thriving in the era of new institutional engineering is the ultimate mission that companies, industries, and organizations are now called to face. Those currently working to implement forward-looking agent-based logics and processes (spanning artificial intelligence, quantum communications, and decentralized networks) within organizations and business — and commercial — dynamics are beginning to understand that the real challenge lies in moving from training models to designing markets. However, this institutional shift from ‘models’ to ‘markets’ (and from solutions to systems) will require not only engineering and economic innovation, but also a profound cultural transformation — a radical change in the paradigms of design, governance, and value through which we have so far interpreted and shaped the (exclusively) human organizational and productive dimension. Moving from the concept of ‘homo economicus’ to that of ‘machina economica’, from the idea of the ‘invisible hand’ to that of the ‘autonomous market’, and from the paradigm of the ‘post-industrial enterprise’ to that of the ‘post-human organization’, will require dismantling and updating deeply rooted — yet now outdated — meanings and mindsets.